The Chetty Lab is focused on neurodevelopmental and psychiatric disorders.

We aim to develop meaningful preclinical disease models in human pluripotent stem cell systems (iPSC) to characterize subtypes of these heterogeneous disorders and illuminate opportunities for therapeutic intervention.

Current projects hone in on the cell and molecular mechanisms contributing to brain overgrowth, such as why unhealthy brain cells are not properly eliminated during development in ASD and similar disorders. Our multi-modal approach emphasizes single-cell RNA-sequencing in iPSC-derived cerebral organoids and functional assays in vivo - integrated with patient-specific neuroimaging, cognitive, and clinical data.